Developing and using the UK Biobank Research Analysis Platform, a large-scale Trusted Research Environment

Oliver Gray and Przemyslaw Stempor, UK BioBank

UK Biobank is a world-leading biomedical resource with data describing the health, lifestyle, physical characteristics, metabolomics, and genetics of half a million UK participants. The UK Biobank Research Analysis Platform (RAP), powered by DNAnexus and Amazon Web Services (AWS), has been designed to accommodate the UK Biobank resource’s vast and dramatically increasing scale, providing accessibility to the data for researchers around the world. Here, we will provide a brief tour of the RAP and the UK Biobank data, and describe how researchers can use the RAP to achieve their scientific aims. We will also discuss the challenges encountered by ourselves and established users of our data in moving from a download-only system to a cloud-based framework.

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